In the 13th-century, western Europe rediscovered Aristotle's books on natural philosophy, or natural science ('Libri naturales'), and this caused an intellectual revolution. Despite being banned in Paris early in the century, they quickly became part of the curricula of universities. Oxford, where this manuscript was probably made, was a leading centre for the study of Aristotle. All students had to read set texts of Aristotle's treatises with commentary, of which this book is an example. It is exceptional, though, because it is quite richly decorated with unusual images. Furthermore, it belonged to Nicholas of Cusa, a German theologian and cardinal, in the 15th century. One of the most demanding texts students had to read, Aristotle's book 'Physics' ('Physicorum') was considered basic to understanding nature. Its fourth section begins with the first letter bearing a picture of a philosopher pointing up to the heavens. Some of the pictures in the manuscript appear to attempt to connect Aristotle's natural science with theology and established views. Above the letter, a man pushes a wheelbarrow in which sits a naked man who appears insane or demented. Perhaps the two pictures are related in that the heavens were believed to influence the minds and bodies of humans.