This study aims to explore how welfare reforms are affecting Deep End General Practices working in Glasgow City, and how they are responding to these issues. In particular, it considers how GPs work with money/welfare advice services, and how this partnership working could be strengthened to ensure that patients receive timely and effective advice and support. Interviews were conducted with six GPs working in some of the most deprived areas of the city, three NHS health improvement staff who had been supporting the delivery of advice services, and three commissioners of advice services from NHS Greater Glasgow and Clyde, Glasgow City Council, and the Wheatley Group, the housing, regeneration and care organisation. The authors noted that GPs were under increasing pressure to deal with paperwork relating to benefit claims for sickness and disability. They also observed that mental health problems associated with delays in processing benefits placed additional burdens on overstretched primary care providers. They suggest that plans to establish a new Scottish social security agency could help to address inequalities among the most vulnerable and excluded citizens.