This brochure contains transcripts from Reform's conference on clinical commissioning. The discussions highlighted the challenge of making clinical commissioning work and delivering value for money in ways that lead to better healthcare. NHS leaders and policy makers need to focus on getting the most from the Government’s reforms. The Commissioning Board will need to allow more flexibility for commissioning groups to capture the potential of clinical leadership and local innovation. As well as retaining the best management and leadership skills, the NHS needs to improve commissioning and the financial skills of clinicians. Commissioners will need to be bold in fostering greater competition between providers and making healthcare responsive to patients. New entrants will be needed to develop working partnerships between primary, secondary and social care.