Orphan medicines: special treatment required?: case study 1: Afinitor and renal cell carcinoma

Document type
Case study
Corporate author(s)
2020health (Think tank)
Date of publication
1 November 2012
Health Services
Social welfare
Material type

Download (138KB )

This case study on the drug Afinitor and treatment of renal cell carcinoma accompanies a report that examines the evidence to see if there are ways of improving decision making on treatments for people with rare diseases in the NHS. Afinitor (everolimus) is an anticancer medicine, manufactured by Novartis. Afinitor has been shown in clinical trials to reduce cancer cells in patients with renal cell carcinoma (RCC), and can lengthen life. RCC is a disease where cancer cells are found in particular tissues of the kidney. It is also known as cancer of the kidney or renal adenocarcinoma.

Afinitor was awarded orphan drug designation for its use in RCC, and approved for use by the European Medicines Agency in 2009. It has subsequently been removed from the Community Register of orphan medicinal products at the request of Novartis.

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